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TFR1 recently has been introduced as a specific ferroptosis marker ( 3+ is reduced to Fe 2+ by the ferrireductase activity of six-transmembrane epithelial antigens of the prostate 3 (STEAP3) in the endosome ( 2+ is subsequently translocated into a labile iron pool (LIP) in the cytoplasm by divalent metal transporter 1 (DMT1, also known as Solute Carrier Family 11 Member 2, SLC11A2) (Ryu et al., 2017)